For example, miRNA-130a can reduce the content of FOSL1, and FOSL1 can promote the expression of the tight junction protein Zona occludens 1 (ZO-1) in breast cancer; thus, miRNA-130a can indirectly inhibit ZO-1 through FOSL1 by inhibiting its expression to inhibit tumor metastasis (73, 74). This evidence concerns the gene FOSL1 and breast cancer.