method, and in the only literature results, it was found that the route of administration of probiotics is one of the most important factors affecting their efficacy, using intranasal administration and oral administration to achieve respiratory resistance, serum specific IgE/IgG2a, lung There are differences and effects on cell infiltration conditions and the performance of cytokines in BALF, which can inhibit allergic asthma symptoms, such as AHR, allergen-specific IgE, Th2 cytokine reduction, and inflammatory cell infiltration (9). This evidence concerns the gene IGHE and allergic asthma.