For example, mutations in TRIM20/pyrin are associated with familial Mediterranean fever (Chae et al., 2003), while mutations occurring in TRIM18/MID1 have been associated with X-linked Opitz G/BBB syndrome (Baldini et al., 2020, Trockenbacher et al., 2001). Here, MEFV is linked to X-linked Opitz G/BBB syndrome.