S100A4 and hepatocellular carcinoma: Regarding clinical diagnosis, we found through ROC curve analysis of TGFβI and S100A4 that their combined detection exhibited a diagnostic sensitivity and specificity for HCC of 71.05% and 90.79%, respectively, with an AUC of 0.842, demonstrating excellent diagnostic efficacy, which can also provide great help for the early diagnosis of HCC in the future.