By IHC and PCR detection, it was observed that TGFβI and S100A4 were higher in cancer tissues than in adjacent tissues, confirming the abnormal upregulation of TGFβI and S100A4 in HCC, which is consistent with the gene sequencing results of Ding Z et al. [6]. The gene discussed is TGFBI; the disease is hepatocellular carcinoma.