In patients with acute myocardial infarction in the first days after the onset of acute chest pain simultaneous monitoring of both tMg2+ and iMg2+ found stable tMg2+ levels and reduced iMg2+ levels, whereby monitoring iMg2+ proved to be clinically rather more useful than monitoring only tMg2+ in these patients [32]. This evidence concerns the gene PRRG2 and acute myocardial infarction.