Disappearance time of CRP, PCT, IL-6, TNF-a, fever, cough, and X-ray infiltrates in M-MPS and H-MPS groups was inferior to that in the L-MPS group (P<0.05), while FVC, MMEF, and PEF were higher (P<0.05). The gene discussed is TNF; the disease is mucopolysaccharidosis.