IL6 and intervertebral disk degenerative disorder: The nucleus pulposus of the herniated disc acts as an autoantigen, triggering an autoimmune response that generates numerous immune and inflammatory factors [4], including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) [5] Elevated levels of C-reactive protein (CRP) have been positively correlated with pain and disc degeneration [6].