EGCG appears to counteract these effects andact on initial metastasis steps, hindering tumor cellular dissociation.While EGCG’s reduction of cancer cell adhesion is establishedin monolayer cultures, its effects inthe three-dimensional cell culture model remain unexplored and warrantfurther investigation into the expression of cell integrity-relatedproteins such as cadherins or integrins. The gene discussed is CDH17; the disease is cancer.