DDX5 and infection: On the other hand, DDX5 was foundto play a pro-viral role by facilitating SARS-CoV-2 infection.−, , , , , ,  Also, viruses have an intimate need for RNA helicases, and a synergicinteraction between viral and host helicases may be insightful, asit could be instrumental to regulate the unwinding of the large viralgenome, especially in the early stage of infection, when the levelof viral helicases is poor.