Additional laboratory workup supported the plasma cell dyscrasia, with elevated LDH and beta-2 microglobulin levels, mild anemia, and a reversed albumin-to-globulin ratio. Cytogenetic analysis revealed high-risk abnormalities, including MYC rearrangement and t(4;14)(IGH::FGFR3) translocation, both of which have been associated with aggressive clinical behavior and poorer prognosis [9,10]. This evidence concerns the gene B2M and anemia.