Serum IL-36α levels in active GPP patients (n=21) (1311±2228 pg/ml) were significantly higher than those in inactive GPP patients (n=5) (30.0±5.4 pg/ml) (p<0.01, Student’s t-test). Similarly, IL-36γ levels in active patients (n=20) were higher (387±661 pg/ml) than those in inactive GPP patients (n=5) (35.6±11.4 pg/ml); however, the difference did not reach statistical significance. The gene discussed is IL36G; the disease is psoriasis 14, pustular.