Previous studies have shown that IL-36g expression in psoriatic epidermis was primarily localized from the suprabasal layer to the granular layer, with minimal expression in the basal layer [18,19]. In line with these findings, our results demonstrated that IL-36γ was primarily detected in the upper layers of the epidermis, in neutrophilic abscesses within the epidermis, and cellular infiltrates below the epidermis. The IL-1/IL-36-chemokine neutrophil axis is suggested as a core molecular pathway in the pathogenesis of pustular psoriasis [18,20,21]. This evidence concerns the gene IL1B and pustular psoriasis.