TFAM and acute kidney injury: Researchers found that PGC-1α deficient mice (Ppargc1a−/− mice) exhibit more severe loss of mitochondrial quality and function during folic acid-induced AKI, as evidenced by the down-regulation of mitochondrial-related genes (Tfam, Ndufs1, and Sdha), reduced TOMM22 staining, and decreased mtDNA, which are correlated with higher levels of kidney injury and inflammation.