Specifically, the Ephrin B2/Eph receptor B4 (EphB4) signaling pathway signaling pathway plays a vital role in sprouting, vascular maturation, and revascularization during tumor angiogenesis and is also integral to the VEGF-Delta-like ligand 4 (Dll4)/Notch-Ephrin B2 pathway.76, 77, 78, 79 Recent studies have revealed additional roles of the Eph system in tumor vascularization. Here, EPHB4 is linked to neoplasm.