AFP and hepatocellular carcinoma: There exists a unique pattern of core and antennary fucosylation in HPT of HCC patients, and the degree of fucosylation was elevated in HCC patients compared with healthy controls and cirrhosis, thereby making fucosylated HPT and the fucosylated HPT/HPT ratio potential markers for the early detection of HCC and the discrimination of HCC from cirrhosis.122, 123, 124, 125 The serum α-fetoprotein (AFP) concentration is the most used marker of HCC.