Studies discovered that intestinal epithelium-specific Fut2 knockout promotes CRC tumorigenesis in mice and overexpression of FUT2 can suppress the proliferation and metastasis of CRC cells, to a certain extent, by regulating α1,2-fucosylation and the functions of melanoma cell adhesion molecule (MCAM) and low-density lipoprotein receptor-related protein 1 (LRP1), which mediate cell adhesion and cell migration. Here, MCAM is linked to colorectal carcinoma.