In a study, an OAV was engineered to express a transgene encoding non-cleavable MICA (MHC class I chain-related polypeptide A), which enhanced NK cell-mediated cytotoxicity, increased IFN-γ and CD107a degranulation secretion, stimulated the immune response against tumor cells, and improved anti-tumor immune responses in mouse models.69 The gene discussed is LAMP1; the disease is neoplasm.