IL2 and neoplasm: In recent studies, researchers successfully engineered OV coding IL-2 to facilitate localized expression of IL-2 within tumors, thereby augmenting the anti-tumor efficacy of OVs, which was validated in in vivo and in vitro experiments.168, 169, 170 For example, Bommareddy et al developed G47Δ-mIL2 (an oHSV expressing IL-2) to deliver IL-2 locally within the TME.171