Recent studies have revealed that BCL6 plays a key role in a variety of tumors, such as acute lymphoid leukemia, chronic myeloid leukemia, breast cancer, and ovarian cancer, and these studies have implicated genomic amplification of the BCL6 locus in tumors.17, 18, 19, 20, 21, 22 In addition, BCL6 was found to be highly expressed in high-grade glioma, and its overexpression inhibited the apoptosis of glioma cells and became an essential factor for the survival of GBM cells. The gene discussed is BCL6; the disease is glioma.