To explore the biological effects of BCL6 in GBM cell lines, we established three BCL6-knockdown GBM cell lines via siBCL6 (Fig. 1E) and found that endogenous BCL6 deletion significantly reduced the viability and colony formation ability of the U87-MG, U251, and SF268 cell lines (Fig. 1F, G). This evidence concerns the gene BCL6 and glioblastoma.