BCL6 and lymphoma: By recruiting three major transcriptional corepressors, SMRT (silencing mediator of retinoic acid and thyroid hormone receptor), NCOR (nuclear receptor corepressor), and BCOR (BCL6 corepressor), to bind to its N-terminal BTB domain, BCL6 is a key molecule in regulating the germinal center (GC) response during humoral immunity in the normal body.14, 15, 16 Failure to terminate BCL6 promptly while B cells are undergoing the GC response can lead to blocked terminal differentiation of B cells and ultimately drive the malignant phenotype of lymphoma.17