VEGFA and neoplasm: Moreover, in colon cancer, ursolic acid inhibits the activation of STAT3, Akt, and sonic hedgehog (SHH) pathways, down-regulates the expression of pro-angiogenic factors VEGF and bFGF, and impedes the proliferation and migration of ECs, thereby exerting an inhibitory effect on tumor angiogenesis (Table 1).118