However, when CHI3L1 combined with other parameters such as waist-to-height ratio, HA, procollagen–III–peptide, CK-18 neoepitope M65, and type IV collagen 7s, to established different diagnostic models, they are quite effective for NAFLD with significant fibrosis (≥F2) and advanced fibrosis (≥F3), the AUROC of each model is more than 0.80 with different cutoff values owing to the different formulas. Here, CHI3L1 is linked to metabolic dysfunction-associated steatotic liver disease.