CHI3L1 can be secreted by various cells, including chondrocytes, synoviocytes, macrophages, neutrophils, fibroblasts, endothelial cells, epithelial cells, and tumor cells.1, 2, 3 Notably, CHI3L1 is enriched in the liver compared with other tissues.4 This evidence concerns the gene CHI3L1 and neoplasm.