CHI3L1 and steatosis: Although CHI3L1 may not be superior for diagnosing HCV-related fibrosis compared with other markers, it can monitor the progression of HBV- and HCV-related fibrosis60, 61, 62 and evaluate the effectiveness of antiviral therapy.63, 64, 65 Notably, CHI3L1 can be secreted by HCV-induced steatotic hepatocytes, and the CHI3L1/AST ratio can diagnose grade II and III steatosis caused by HCV.66