Additionally, SOX2 modulates the expression of various growth factors, angiogenesis factors, and lymphangiogenesis factors, such as neuropilin-2 (NRP2), fibroblast growth factor 2 (FGF2), and vascular endothelial growth factor C (VEGFC), thereby promoting the ability of PCa cells to enter the circulatory system, which is a key step in metastasis.22 Here, NRP2 is linked to posterior cortical atrophy.