SOX2 and neoplasm: For example, Lovnicki et al98 analyzed tumor samples from NEPC patients, patient-derived xenograft models, transgenic mice, and cell models, finding that lin-28 homolog B (LIN28B) up-regulation could activate the stem-cell-like gene network via the Lin28B/let-7/SOX2 axis, driving the expression of NE markers and promoting NEPC progression.98