Vaddi et al76 demonstrated that in human PCa cell lines with SOX2/OCT4 overexpression (SORE6+), the phosphorylation level of AKT was significantly elevated compared with SORE6-cells, although the total AKT level and the catalytic subunits of PI3K, p110α and p110β, remained unchanged. Here, SOX2 is linked to posterior cortical atrophy.