In both breast and PCa cell lines, SOX2 further modulates the activity of the WNT signaling pathway by regulating key regulators or downstream effector molecules of the pathway, such as dickkopf WNT signaling pathway inhibitor 3 (DKK3), dishevelled-1 (DVL1), and DVL3. The gene discussed is DKK3; the disease is posterior cortical atrophy.