SOX2 and neoplasm: Similarly, Vêncio et al73 used lentiviral vectors carrying POU class 5 homeobox 1 (POU5F1), LIN28, NANOG, and SOX2 to transfect CD90+ PCa-associated stromal cells—a distinct pathological cell type exclusive to tumor tissues—successfully generating alkaline phosphatase-positive induced pluripotent stem cells.