The RAB family plays a key role in epithelial neoplasia, and its high expression in cancer is often associated with cancer metastasis and progression.34, 35, 36 Studies have shown that RAB2A can directly interact with MAPK phosphatase and prevent the dephosphorylation of Erk1/2, which enhances the tumorigenicity of breast cancer stem cells. The gene discussed is MAPK3; the disease is breast carcinoma.