For example, RAB3D, RAB7, RAB11, RAB23, and RAB25 promote cancer cell proliferation, migration, invasion, and metastasis by disrupting the homeostasis of intracellular signal transduction and vesicular trafficking in PCa.17, 18, 19, 20, 21, 22 However, only a few fractions of RAB proteins are implicated in cancer stemness. This evidence concerns the gene RAB25 and cancer.