NFE2L2 and cancer: Remarkably, certain chemotherapeutics, including radiotherapy and cisplatin, can induce oxidative stress, leading to NRF2 activation.156, 157, 158, 159, 160 Optimizing NRF2 inhibitor and chemoradiotherapy dosing may improve their combined effectiveness, while targeting NRF2 inhibition specifically in cancer cells could reduce toxic side effects in normal tissues.