Fangchinoline effectively suppresses metastasis in non-small-cell lung cancer by inducing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase 4 (NOX4) degradation, which inhibits cytosolic ROS-mediated protein kinase B (AKT)-mammalian target of the rapamycin (mTOR) signaling and subsequently disrupts epithelial–mesenchymal transition, invasion, and metastasis.151. This evidence concerns the gene MTOR and non-small cell lung carcinoma.