Our benefits in the BDI and PHQ-9 subgroups are consistent with the anti-inflammatory and neurotrophic effects of vitamin D. Calcitriol inhibits the activity of NF-κB and NLRP3 inflammasomes, which may preferentially improve anhedonia and low energy (captured by BDI/PHQ-9) rather than the somatic/insomnia symptoms highlighted in HAMD/EPDS. The gene discussed is NLRP3; the disease is insomnia.