Upregulation of GAL3 has been observed in a variety of critically-ill patients on ICU presenting with sepsis, trauma or COVID-19.29, 30, 31 In addition, elevation of GAL3 was reported in patients with severe heart failure with need for mechanical circulatory support and acute myocardial infarction (AMI) with hemodynamic instability.32, 33 Two studies have previously revealed GAL3 elevation on hospital admission in serum of OHCA patients.13, 14 The present study is the first to analyze the temporal profile of GAL3 beyond admission during the early post-resuscitation period (Fig. 1). The gene discussed is LGALS3; the disease is heart failure.