This pattern aligns with findings in stroke and ST-elevation myocardial infarction patients, where GAL3 levels peaked during ischemia and declined after reperfusion.34, 35 Similarly, in our OHCA cohort, the initial GAL3 peak likely reflects no-flow/low-flow ischemia during resuscitation, while the subsequent decrease indicates reperfusion. The gene discussed is LGALS3; the disease is Stroke.