Based on previous reports, the p50/RelB complex of the NF‐κB pathway acts as an upstream regulator, directly activating PCLAF transcription, promoting its expression, and driving nasopharyngeal carcinoma proliferation and metastasis.[16] This prompted us to investigate whether CLTB mediates HCC progression by regulating aberrant PCLAF expression via the NF‐κB signaling pathway. Here, PCLAF is linked to hepatocellular carcinoma.