NFKB1 and neoplasm: As a central regulatory hub in inflammation‐related tumorigenesis, aberrant activation of NF‐κB mediates enhanced proliferation and inhibition of apoptosis in tumor cells.[28] Experimental evidence suggests that CLTB maintains sustained activation of the NF‐κB signaling pathway by promoting IκBα and p65 phosphorylation modification, thereby upregulating the PCLAF expression level.