SH3KBP1 (also known as CIN85) is a multifunctional junction protein containing three SH3 structural domains that promotes tumor invasion and regulates actin remodeling.[29, 30, 31] Previous studies have reported that CBL mediates the mono‐ubiquitination of SH3KBP1 through its interaction with SH3KBP1.[17] CLTB interacted and co‐localized with SH3KBP1 in HUVECs, with a substantial positive connection in expression levels. Here, CBL is linked to neoplasm.