Clinicopathological analysis revealed that elevated CLTB expression was significantly associated with cirrhosis (p = 0.047), but showed no correlations with sex, age, tumor characteristics (count, microsatellite status), histopathological features (Edmonson‐Steiner grade, TNM stage), viral hepatitis status (HBV/HCV), and serum AFP levels. Here, CLTB is linked to Cirrhosis.