The activation of peroxisome proliferator‐activated receptor gamma promotes macrophage polarization to the M2 phenotype and improves insulin sensitivity;[24] liver X receptor can exert anti‐atherosclerosis effects by promoting cholesterol clearance by macrophages.[25] In the present study, CAR was found to be abundant in both human and murine macrophages, suggesting that CAR is a potential target for modulating macrophage function. This evidence concerns the gene INS and atherosclerosis.