Ten days following tumor cell injection, the mice were randomized into three groups and treated with EVs isolated from i) ID8 Trp53−/−;Brca2−/− cells, ii) ID8 Trp53−/−;Brca2−/– cells that overexpressed eIF4E, or iii) eIF4E knock down ID8 Trp53−/−;Brca2−/− cells. The gene discussed is EIF4E; the disease is neoplasm.