While miRNA‐mediated regulation is a well‐established mechanism by which cancer cell derived EVs can modulate PD‐L1 expression in recipient immune cells,[58] both in vitro and in vivo experiments consistently demonstrated that the observed increase in PD‐L1 expression in macrophages is primarily driven by EV‐mediated eIF4E signaling. The gene discussed is EIF4E; the disease is cancer.