These findings show that exogenously administered eIF4E‐packed EVs selectively induce the upregulation of CD206 and PD‐L1 expression in macrophages, thereby fostering the emergence of immunosuppressive macrophages within the tumor.[37, 38] To investigate the impact of tumor derived eIF4E‐EVs on macrophage functionality, a cytokine array was conducted using the macrophage supernatant. This evidence concerns the gene CD274 and neoplasm.