To assess the effects of pharmacological inhibition of cholesterol on tumor growth and macrophage activation, ID8 Trp53−/−;Brca2−/– cells were orthotopically injected into syngeneic C57BL/6 mice and treated with HMGCR inhibitor simvastatin (Figure 7H and Figure S7B, Supporting Information). Here, HMGCR is linked to neoplasm.