EIF4E and ovarian cancer: In vivo data demonstrated that C57BL/6 female mice implanted with ID8 Trp53−/−;Brca2−/− murine ovarian cancer cell lines overexpressing eIF4E or eIF4A1 exhibited an increased volume of ascites and tumor burden within the peritoneal cavity compared to the control group (Figure 1H–J and Figure S1M–P, Supporting Information).