CD274 and neoplasm: However, these macrophages displayed notable phenotypic alterations, evidenced by increase in PD‐L1 and CD206 expression in eIF4E‐EVs group, despite comparable overall counts (Figure 6P,Q) In contrast, the number of macrophages in peritoneal wash samples from naïve mice was significantly lower than in tumor bearing mice, suggesting that tumor progression promotes both macrophage recruitment and phenotypic reprogramming (Figure S6L, Supporting Information).