PRRT2 and hydrops fetalis: Delving further into the literature, other HF hub signalling mechanisms have begun to emerge including the Phospholipase Cβ1/protein kinase C/inositol triphosphate (PLCβ1/PKC/IP3) pathway, protein kinases A and G (PKA, PKG), and nuclear factor κB (NF‐κB) pathway 10, 11 While these signalling proteins have been targeted for reversing HF, most studies have targeted them individually resulting in limited effects.