Importantly, high expression of TGF-β1 has been correlated with poor survival in iCCA patients.20 Accordingly, we found that high expression of TGFBR1 and TGFBR2 receptors also correlates with poor survival in a cohort of 246 iCCA patients (GSE244807) (Fig. 1d). The gene discussed is TGFBR1; the disease is infantile convulsions and choreoathetosis.