CD274 and infantile convulsions and choreoathetosis: Nevertheless, we also observed increased CD4 T cell infiltration in the setanaxib group, which is probably facilitated by the reduction of intratumoural fibrosis, as previously shown.36 Importantly, another recent study correlated intratumoural CD4 T cell infiltration with better survival in iCCA patients.49 In this regard, our simulation of iCCA stratification based on the setanaxib signature obtained in vitro in HSC rendered similar results: reduced PD-L1 expression, increased CD4 infiltration and an improved survival in iCCA patients.