NOX4 and neoplasm: Setanaxib had no impact on the size of spheroids formed by tumour cells alone or in combination with TMNK1 endothelial cells or THP-1 macrophages (Supplementary Fig. 28) but significantly reduced the growth of mixed spheroids (Fig. 6c), demonstrating the specificity of setanaxib on liver myofibroblasts, the only NOX4/NOX1 expressing cells.