There is increasing evidence that oxidative stress may be an important modulator of liver fibrosis (Li et al. 2015; Ma et al. 2022), and that apolipoprotein A4 (APOA4) and collagen IV could serve as biomarkers in this context (Lønsmann et al. 2023; Wang et al. 2017). This evidence concerns the gene APOA4 and Hepatic fibrosis.