Remarkably, increased expression of APOA4 is considered an early marker for liver fibrosis in humans (Wang et al. 2017) and has been observed in various models, including fibrosis in rhesus macaque (Feng et al. 2023) or alcoholic hepatitis in human and mice models (Li et al. 2022). The gene discussed is APOA4; the disease is Hepatic fibrosis.