Reduced adiponectin plasma levels have been also observed in various liver diseases such as non-alcoholic steatohepatitis (NASH), non-alcoholic fatty liver disease (NAFLD), or hepatocellular carcinoma (HCC) (Gamberi et al. 2018; Shabalala et al. 2020). The gene discussed is ADIPOQ; the disease is metabolic dysfunction-associated steatohepatitis.