Recent research has leveraged 2 of these large population datasets, UK Biobank and gnomAD, to reevaluate the BLK, KLF11, and PAX4 genes, over which there were already doubts regarding their pathogenicity.4 This showed that many of the published variants were now in population databases at too high frequency to cause MODY and that the cosegregation in the original pedigrees was limited. This evidence concerns the gene PAX4 and MODY.