Bromodomain-containing protein 4 (BRD4), an epigenetic regulator that specifically recognizes and binds to acetylated histones through its bromodomain and then acts as a scaffold protein to recruit the transcription elongation factor b (P-TEFb) complex to facilitate the transcription of acetylated chromatin regions, plays a crucial role in the onset and progression of various diseases, including thyroid cancer [59–61]. The gene discussed is BRD4; the disease is thyroid cancer.