The results of ELISA showed the expression levels of interleukins-4, and IL-6 and it showed that psoriasis highly increases the expression of the both interleukins and that psoriasis promotes the inflammatory effects and then demonstrated that the applying treatment can reduce these inflammatory effect by decreasing the expression levels of the interleukins-4, and IL-6.where, the EGCG nanoparticles- loaded exosomes showed the best anti-inflammatory effects as compared with the other treatments These results were in agreement with the results obtained by35. The gene discussed is IL4; the disease is psoriasis.