Much research has been done to detect the main effect mesenchymal stem cells on skin diseases, specifically psoriasis which elevates the expression of SOD3 and inhibits the progression as well as severity of psoriasis by regulating immune cell functions and infiltration particularly dendritic cells, Th17 cells, neutrophils and through controlling TLR-7-dependent, MAP kinases, epidermal functions6. The gene discussed is SOD3; the disease is psoriasis.