6 h after the L2T+ tumor cells were inoculated into the tail vein of immune competent Balb/c mice, the blood CTC analyses also revealed that Plxnb2 KD reduced heterotypic CTC clustering with monocytes (Fig. 6c), which possibly provided opportunities for other WBCs (such as T cells) to interact with 4T1 tumor cells (Supplementary Fig. S9c-e). Here, PLXNB2 is linked to neoplasm.