Groups C and F, with clustering-specific up-regulation and down-regulation in protein expression, respectively, identified pathways in protein folding and hydroxylation, UV protection, and response to gamma radiation, all of which were over 10-fold enriched in PLXNB2+ tumor cell clusters (Supplementary Fig. S7a and Supplementary Table S1). This evidence concerns the gene PLXNB2 and neoplasm.