Moreover, KD of CDC42, a known target of PLXNB2 signaling64 and a component of the PLXNB2 protein complex (Fig. 4c), mimicked the KD of PLXNB2 and MCM7 in reducing efficiencies of mammosphere formation and tumor cell clustering in vitro (Supplementary Fig. S7i–k). Here, CDC42 is linked to neoplasm.