With minimal clustering capacity, the PB2 KO cells showed a significant reduction in tumor cell dissemination to the lungs after 12 h, and the phenotype was maintained for up to four days (Fig. 5n), suggesting that PLXNB2 enhances dissemination and metastatic colonization, coupled with tumor clustering and independent of proliferation effects. The gene discussed is PLXNB2; the disease is neoplasm.