SEMA4A+ monocytes with PLXNB2+ tumor cells (double positive) formed the largest clusters with more cell counts per cluster and in highest numbers of clusters compared to single-negative or double-negative combinations of SEMA4A−/+ monocytes with PLXNB2+/− tumor cells in heterotypic clustering (Fig. 5l, m, Supplementary Fig. S8i, and S9a–b). Here, PLXNB2 is linked to neoplasm.