A recent study by Borrelli et al. has identified PLXNB2 as a crucial host-derived regulator of liver colonization in colorectal and pancreatic cancer through its interactions with class IV semaphorins on tumor cells, leading to the upregulation of KLF4 and promoting the acquisition of epithelial traits86,86. Here, KLF4 is linked to familial pancreatic carcinoma.