By Day 9 when two groups of tumors developed into comparable sizes (tumor weight), the Plxnb2-KO tumor group significantly reduced spontaneous metastases to the lungs, coupled with decreased CTCs, both singles and CTC-WBC clusters, particularly the CTC-myeloid clusters (Fig. 6e–i), as analyzed by bioluminescence imaging and flow cytometry. This evidence concerns the gene PLXNB2 and neoplasm.