PLXNB2 and neoplasm: Notably, the tumor growth phenotype of stable PLXNB2 KO tumor cells (via Cas9/gRNAs) might have resulted from selective pressure in KO cell maintenance, differing from the variable effects of siRNA-mediated transient KD of PLXNB2 in our following studies (shown in Supplementary Fig. S5) as well as the reported inhibitory effects of shRNA-mediated PLXNB2 knockdown (KD) on tumor cell proliferation51.