These PLXNB2 KO cells did not significantly alter cellular growth (confluence), viability, cell migration, and invasion in vitro as well as 10,000 tumor cell-mediated growth curves in vivo (Supplementary Fig. S4a–h) whereas the tumorigenesis in serial dilutions of 10 to 1000 cell implants was compromised (Supplementary Fig. s4i–k). The gene discussed is PLXNB2; the disease is neoplasm.