MCM7 and neoplasm: Moreover, KD of CDC42, a known target of PLXNB2 signaling64 and a component of the PLXNB2 protein complex (Fig. 4c), mimicked the KD of PLXNB2 and MCM7 in reducing efficiencies of mammosphere formation and tumor cell clustering in vitro (Supplementary Fig. S7i–k).