However, subsequent immunoblotting analysis revealed a truncated form of PLXNB2 (also known as β subunit42) in breast cancer cell-derived EVs which did not contain the full-length protein (Supplementary Fig. S1e), therefore the PLXNB2 functions in EVs were not further investigated and we focused on characterizing its cellular functions instead in this study. The gene discussed is PLXNB2; the disease is breast carcinoma.