IL4 and Alzheimer disease: The pronounced expression of the CB1 and CB2 receptors in immune cells and lymphoid tissues involved in innate and adaptive immune responses makes the use of cannabidiol a potential mediator of inflammatory responses (Ruhl et al. 2021; Laprairie et al. 2015) I. In a study involving knockout animals, the absence of the CB1 receptor increased IL-4, TSLP and CCL-8 levels as well as increased neutrophil activity, in addition to delaying epithelial barrier repair, as observed in AD patients (Gaffal et al. 2014).