Here, we explore this critical gap in understanding epidermal lipid metabolism by examining frequent ABHD5 point mutants (Fig. 1A) to decipher the molecular mechanism underlying ichthyosis pathogenesis in ABHD5-sEDD (4, 22, 23, 24, 25, 26, 27, 28, 29, 30). This evidence concerns the gene ABHD5 and ichthyosis.