PAF1 and lung cancer: To sum up, in NSCLC, BAP18 is recruited to the promoter region of Wnt target genes, where it facilitates the recruitment of β-catenin, ACTL6A, and PAF1, and enhances the levels of histone modifications H3K4me3 and H4ac, promoting transcriptional activation of Wnt–β-catenin target genes and enhancing lung cancer cell proliferation and migration (Fig. 7G).