Moreover, reports of correlation between tau accumulation rates and connectivity strength to tau epicenters (Franzmeier et al., 2020), as well as of spatial association of functional connectivity changes with microglial activation in Aβ- and tauopathies such as Alzheimer’s disease (Rauchmann et al., 2022) suggest high utility of fcMRI-based biomarkers in diagnosis and prognostication of neurodegeneration. This evidence concerns the gene MAPT and tauopathy.