ADF (actin-depolymerizing factor), AJC (apical junctional complex), C (cancer), DEGs (differentially expressed genes), EMT (epithelial-mesenchymal transition), F (fibrosis), FDR (false discovery rate), GEO (Gene Expression Omnibus), GSEA (Gene Set Enrichment Analysis), KEGG (Kyoto Encyclopedia of Genes and Genomes), L (leukoplakia), N (non-pathology), NCBI (National Center for Biotechnology Information), OSCC (oral squamous cell carcinoma), OSF (oral submucous fibrosis), RNA-seq (RNA sequencing), and TCGA (The Cancer Genome Atlas). The gene discussed is DSTN; the disease is cancer.