High cortisol/DHEAS ratio has been associated with cognitive decline, immunosuppression, hypertension, and metabolic disorders resulting from the imbalance between cortisol and DHEAS (Butcher et al. 2005; Carvalhaes-Neto et al. 2003; De Bruin et al. 2002; Phillips et al. 2010). The gene discussed is SULT2A1; the disease is Other metabolic disease.