TRIM63 and Atrophy: Depletion of macrophages using clodronate liposomes reversed the beneficial effects of ES on induced masseter atrophy (MuRF1: BTX + ES: 2.20 ± 0.16; BTX + ES + CL: 12.93 ± 0.98, p < 0.0001), highlighting the involvement of macrophages in the therapeutic process.