The median expression of DERs in neuronal cells (APP, BAZ2B, CREB5, KCNH8, ST18, ZBTB20, ZEB2, ZNF536) were reduced in AD compared to controls (Figure 2j), and were downregulated with increasing age (see Figure S1), and in individuals with higher Braak stages (> stage 4) and specific APOE alleles (e3/e4 and e4/e4) (Figure 2j and Figure S1b,c). The gene discussed is CREB5; the disease is Alzheimer disease.