Thus, we have identified common DERs driving AD in specific brain areas and with distinct expression patterns in myeloid (MEF2A, MEF2C, HIVEP3, ETV6) and neuronal cells (APP, BAZ2B, MYRF, NFIB, PAX6, ST18, ZEB2, SOX10, NKX6‐2, CREB5, KCNH8, ZNF536), and in sex (TCF4, MAFB, THRB, FOSL2, ZEB2, KCNH8). Here, MEF2C is linked to Alzheimer disease.