Thus, we have identified common DERs driving AD in specific brain areas and with distinct expression patterns in myeloid (MEF2A, MEF2C, HIVEP3, ETV6) and neuronal cells (APP, BAZ2B, MYRF, NFIB, PAX6, ST18, ZEB2, SOX10, NKX6‐2, CREB5, KCNH8, ZNF536), and in sex (TCF4, MAFB, THRB, FOSL2, ZEB2, KCNH8). Here, HIVEP3 is linked to Alzheimer disease.