CDH1 and medullary thyroid gland carcinoma: This phenomenon aligns with our previous findings in the MTC (Trp53−/−; Cdh1−/−) gastric cancer model, where Trim6 knockout similarly suppressed the tumor growth of MTC cells in C57BL/6J mice (Fig. 2a), reinforcing the role of TRIM6 across different MSS-type gastric tumor models.