ISG15 and gastric cancer: Conversely, TRIM6 depletion in mouse (MTC) and human (MKN28) gastric cancer cells resulted in a significant increase in the mRNA levels of IFNB1 and its downstream genes CXCL10 and ISG15 (or Ccl5) under HT-DNA treatment, and these effects were abolished by simultaneous cGAS knockout (Fig. 5b and c).