Through genetic ablation studies in both MSS/MSI-low gastric cancer cell lines and murine MSS models, we show that TRIM6 deletion restores cGAS protein stability, reactivates the cGAS-STING-IFNβ signaling axis (Fig. 6e), and enhances antitumor immunity. This evidence concerns the gene IFNB1 and Marinesco-Sjogren syndrome.