Each variable (Xi) is assigned a value of 1 if the condition is met, or 0 otherwise: X1 = QTc prolongation at baseline; X2 = Potassium < 3.5 mmol/L; X3 = Calcium < 8 mmol/L; X4 = Albumin < 3.8 g/dL; X5 = AST ≥ 105 IU/L; X6 = ECG performed in the emergency room; X7 = Presence of cardiovascular diseases excluding those strongly associated with QTc prolongation (e.g., arrhythmia, ischemic heart disease, hypertension, heart failure, cardiomyopathy); X8 = Total bilirubin > 2 mg/dL; X9 = ECOG score ≥ 3; X10 = Concurrent use of ≥ 5 medications; X11 = INR > 1.5; X12 = Presence of arrhythmia. The gene discussed is ALB; the disease is heart failure.