A statistically significant higher CRP concentration (U = 478.00, Z = −5.75, P < 0.001), a higher HES (U = 879.00, Z = −7.73, P < 0.001), and higher levels of parasitemia (U = 252.00, Z = -8.00, P < 0.001) were observed in seronegative dogs compared with seropositive dogs (Fig. 3). This evidence concerns the gene CRP and parasitic infectious disease.