Aiming to further enhance the predictive accuracy for RP-ILD, we used the ROC curves to evaluate the discriminative capacities of high titers of anti-MDA5 IgG1 (≥ 1:100) in combination with an elevated of NLR, CRP, anti-Ro52 antibody, and serum ferritin (SF). This evidence concerns the gene TRIM21 and interstitial lung disease.