Additionally, the top Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with COL1A1, ITGB1, THY1, and PDGFRA genes included pathways such as “ECM receptor interaction, leukocyte transendothelial migration, platelet activation, focal adhesion, and glioma” among others (Fig. 8D). This evidence concerns the gene COL1A1 and central nervous system cancer.