LGMN and Alzheimer disease: To assess whether NP-11a-isopropyl administration efficiently blocks AEP protease activity, we employed 6-month-old 3xTg AD mice and analyzed AEP enzymatic activity and the fragmentation of its downstream targets in the brain lysates 2 ​h after oral gavage of 7.5 ​mg/kg and 15 ​mg/kg of drug (Fig. 4A).