Notably, several mitochondrial genes, including MT-ND3 and MT-ATP6, were upregulated in YN, MN, and ASC of D60 fAD organoids, consistent with the results of a recent scRNA-seq analysis of a large cohort of AD patients, whose mitochondrial gene expression was significantly upregulated in excitatory neurons, astrocytes, and microglia (Mathys et al., 2023). Here, MT-ATP6 is linked to Alzheimer disease.