Wild-type and Fgf15 transgenic (Fgf15 Tg) mice were fed a high-fat diet (HFD) to induce MASH, then a PPARα agonist was subsequently administered to a subcohort of HFD groups to study the synergistic effect of Fgf15 overexpression and PPARα activation. The gene discussed is PPARA; the disease is metabolic dysfunction-associated steatohepatitis.