PPARA and metabolic dysfunction-associated steatohepatitis: However, emerging study also found that intestinal PPARα activation promotes nonalcoholic steatohepatitis progression by inducing the expression of liver FA–binding protein 1 and thus increasing FA–binding protein 1–mediated uptake of dietary FAs,33 indicating the tissue-specific functions for PPARα activation in lipid metabolism, which could also explain the different outcomes between this and previous studies.