Furthermore, in an independent xenograft model where NRGS (NOD-Rag1−/−IL2Rγnull SirpαNOD) mice were transplanted with MOLM13 cells expressing luciferase, the treatment of FP54 also notably reduced the leukemia burden, delayed disease onset, and prolonged survival in the treated mice (Fig. 5, H and J). This evidence concerns the gene RAG1 and leukemia.